Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.
Annu Rev Cell Dev Biol
; 32: 649-675, 2016 10 06.
Article
in En
| MEDLINE
| ID: mdl-27576121
ABSTRACT
In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteogenesis
/
Blood Vessels
/
Signal Transduction
/
Hematopoiesis
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Cell Dev Biol
Journal subject:
BIOLOGIA
Year:
2016
Type:
Article