Cyclosporine Reduces Sclerosis in Morphea: A Retrospective Study in 12 Patients and a Literature Review.
Dermatology
; 232(4): 503-10, 2016.
Article
in En
| MEDLINE
| ID: mdl-27576516
ABSTRACT
BACKGROUND:
The treatment of severe morphea is challenging, and treatment experience concerning the use of immunosuppressive agents for this condition is limited.OBJECTIVE:
The purpose of this study is to analyze the use of cyclosporine, its tolerability, and its effect on skin sclerosis. MATERIALS ANDMETHODS:
Patients with severe morphea who underwent treatment with cyclosporine were studied retrospectively.RESULTS:
Five of 12 patients with morphea showed complete remission and 6 patients had partial remission at the end of therapy (9-46 months, median 14) under a median cyclosporine dose of 2.4 mg/kg. The mean affected body surface area fell from 50% (2-80, median 65) to 17% (0-40, median 18). Side effects were hypertension, elevated transaminases, cholesterol, and weight gain.CONCLUSION:
Cyclosporine can be effective in morphea. The side effects were reversible. However, the duration of treatment with cyclosporine is limited because of its potential permanent side effects. Prospective placebo-controlled studies are needed to establish the superiority of cyclosporine over other immunosuppressive drugs in this setting.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scleroderma, Localized
/
Skin
/
Remission Induction
/
Cyclosporine
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Dermatology
Journal subject:
DERMATOLOGIA
Year:
2016
Type:
Article
Affiliation country:
Hungary