Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin.

Shearer, Andrew M; Rana, Rajashree; Austin, Karyn; Baleja, James D; Nguyen, Nga; Bohm, Andrew; Covic, Lidija; Kuliopulos, Athan

Shearer, Andrew M; Rana, Rajashree; Austin, Karyn; Baleja, James D; Nguyen, Nga; Bohm, Andrew; Covic, Lidija; Kuliopulos, Athan.

Affiliation

Shearer AM; From the Center for Hemostasis and Thrombosis Research, Molecular Oncology Research Institute, Tufts Medical Center and.
Rana R; Tufts University School of Graduate Biomedical Sciences, Biochemistry/Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Austin K; From the Center for Hemostasis and Thrombosis Research, Molecular Oncology Research Institute, Tufts Medical Center and.
Baleja JD; From the Center for Hemostasis and Thrombosis Research, Molecular Oncology Research Institute, Tufts Medical Center and.
Nguyen N; Tufts University School of Graduate Biomedical Sciences, Biochemistry/Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Bohm A; Tufts University School of Graduate Biomedical Sciences, Biochemistry/Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Covic L; From the Center for Hemostasis and Thrombosis Research, Molecular Oncology Research Institute, Tufts Medical Center and.
Kuliopulos A; Tufts University School of Graduate Biomedical Sciences, Biochemistry/Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.

J Biol Chem ; 291(44): 23188-23198, 2016 10 28.

Article in En | MEDLINE | ID: mdl-27613872

Subject(s)

Lipopeptides/administration & dosage; Liver Cirrhosis/prevention & control; Receptor, PAR-2/metabolism; Animals; Hepatocytes; Humans; Liver/drug effects; Liver/metabolism; Liver Cirrhosis/genetics; Liver Cirrhosis/metabolism; Male; Mice; Mice, Inbred C57BL; Reactive Oxygen Species/metabolism; Receptor, PAR-2/antagonists & inhibitors; Receptor, PAR-2/genetics

Key words

G protein-coupled receptor (GPCR); PAR2; biotechnology; cell-penetrating peptide (CPP); fibrosis; pepducin; reactive oxygen species (ROS)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, PAR-2 / Lipopeptides / Liver Cirrhosis Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Biol Chem Year: 2016 Type: Article

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