GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.

Egholm, Cecilie; Khammy, Makhala Michell; Dalsgaard, Thomas; Mazur, Aleksandra; Tritsaris, Katerina; Hansen, Anker J; Aalkjaer, Christian; Dissing, Steen

Egholm, Cecilie; Khammy, Makhala Michell; Dalsgaard, Thomas; Mazur, Aleksandra; Tritsaris, Katerina; Hansen, Anker J; Aalkjaer, Christian; Dissing, Steen.

Affiliation

Egholm C; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Khammy MM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dalsgaard T; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mazur A; Department of Biomedicine, Aarhus University, Aarhus, Denmark; and.
Tritsaris K; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Hansen AJ; Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Aalkjaer C; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dissing S; Department of Biomedicine, Aarhus University, Aarhus, Denmark; and.

Am J Physiol Heart Circ Physiol ; 311(5): H1214-H1224, 2016 11 01.

Article in En | MEDLINE | ID: mdl-27638877

Subject(s)

Endothelial Cells/drug effects; Glucagon-Like Peptide 1/pharmacology; Glucagon-Like Peptide-1 Receptor/genetics; Mesenteric Arteries/drug effects; Vascular Endothelial Growth Factor A/pharmacology; Vasodilation/drug effects; Animals; Calcium/metabolism; Dermis/blood supply; Endothelial Cells/metabolism; Enzyme Inhibitors/pharmacology; Glucagon-Like Peptide 1/analogs & derivatives; Humans; Male; Mesenteric Arteries/metabolism; Mitogen-Activated Protein Kinase 1/drug effects; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/drug effects; Mitogen-Activated Protein Kinase 3/metabolism; NG-Nitroarginine Methyl Ester/pharmacology; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase Type III/drug effects; Nitric Oxide Synthase Type III/metabolism; Phospholipase C gamma/drug effects; Phospholipase C gamma/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins pp60(c-src)/drug effects; Proto-Oncogene Proteins pp60(c-src)/metabolism; RNA, Messenger/metabolism; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Retinal Vessels/cytology; Vascular Endothelial Growth Factor Receptor-2/drug effects; Vascular Endothelial Growth Factor Receptor-2/metabolism

Key words

GLP-1R; PLCÎ³ and eNOS; VEGFA signaling; endothelial cells; vasodilation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Endothelial Cells / Vascular Endothelial Growth Factor A / Glucagon-Like Peptide 1 / Glucagon-Like Peptide-1 Receptor / Mesenteric Arteries Limits: Animals / Humans / Male Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2016 Type: Article Affiliation country: Denmark

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