Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis.

Brilha, Sara; Sathyamoorthy, Tarangini; Stuttaford, Laura H; Walker, Naomi F; Wilkinson, Robert J; Singh, Shivani; Moores, Rachel C; Elkington, Paul T; Friedland, Jon S

Brilha, Sara; Sathyamoorthy, Tarangini; Stuttaford, Laura H; Walker, Naomi F; Wilkinson, Robert J; Singh, Shivani; Moores, Rachel C; Elkington, Paul T; Friedland, Jon S.

Affiliation

Brilha S; 1 Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Sathyamoorthy T; 2 Centre for Inflammation and Tissue Repair, Respiratory Medicine, University College London, London, United Kingdom.
Stuttaford LH; 1 Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Walker NF; 1 Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Wilkinson RJ; 1 Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Singh S; 3 Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Moores RC; 4 Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Elkington PT; 3 Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Friedland JS; 5 Department of Medicine, Imperial College London, London, United Kingdom.

Am J Respir Cell Mol Biol ; 56(2): 223-232, 2017 Feb.

Article in En | MEDLINE | ID: mdl-27654284

Subject(s)

Antigens, Bacterial/metabolism; Bacterial Proteins/metabolism; Gene Expression Regulation, Enzymologic; Matrix Metalloproteinase 10/genetics; Matrix Metalloproteinase 10/metabolism; Tuberculosis/genetics; Tuberculosis/microbiology; Amino Acid Sequence; Antigens, Bacterial/chemistry; Bacterial Proteins/chemistry; Epithelial Cells/metabolism; Fibroblasts/metabolism; Humans; Lung/pathology; Macrophages/metabolism; Macrophages/microbiology; Matrix Metalloproteinase 1/metabolism; Mitogen-Activated Protein Kinases/metabolism; Mycobacterium tuberculosis/pathogenicity; NF-kappa B/metabolism; Tuberculosis Vaccines/immunology; Virulence

Key words

early secretory antigenic target-6; matrix metalloproteinases; tuberculosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Tuberculosis / Gene Expression Regulation, Enzymologic / Matrix Metalloproteinase 10 / Antigens, Bacterial Limits: Humans Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2017 Type: Article Affiliation country: United kingdom

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