Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy.

Barker-Haliski, Melissa L; Heck, Taylor D; Dahle, E Jill; Vanegas, Fabiola; Pruess, Timothy H; Wilcox, Karen S; White, H Steve

Barker-Haliski, Melissa L; Heck, Taylor D; Dahle, E Jill; Vanegas, Fabiola; Pruess, Timothy H; Wilcox, Karen S; White, H Steve.

Affiliation

Barker-Haliski ML; Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, Utah, U.S.A.
Heck TD; Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, U.S.A.
Dahle EJ; Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, Utah, U.S.A.
Vanegas F; Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, Utah, U.S.A.
Pruess TH; Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, Utah, U.S.A.
Wilcox KS; Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, Utah, U.S.A.
White HS; Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, Utah, U.S.A.

Epilepsia ; 57(12): 1958-1967, 2016 12.

Article in En | MEDLINE | ID: mdl-27739576

Subject(s)

Anticonvulsants/therapeutic use; Behavior, Animal/drug effects; Epilepsy, Temporal Lobe; Minocycline/therapeutic use; Theilovirus/pathogenicity; Valproic Acid/therapeutic use; Animals; Anxiety Disorders/drug therapy; Anxiety Disorders/etiology; Body Weight/drug effects; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe/drug therapy; Epilepsy, Temporal Lobe/etiology; Epilepsy, Temporal Lobe/virology; Exploratory Behavior/drug effects; Mice; Motor Activity/drug effects; Psychomotor Performance/drug effects; Rotarod Performance Test

Key words

Acquired epilepsy; Anxiety-like behavior; Minocycline; Seizure threshold; Temporal lobe epilepsy; Valproic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Behavior, Animal / Valproic Acid / Theilovirus / Epilepsy, Temporal Lobe / Minocycline / Anticonvulsants Type of study: Etiology_studies Limits: Animals Language: En Journal: Epilepsia Year: 2016 Type: Article Affiliation country: United States

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