Glycine Regulates Protein Turnover by Activating Protein Kinase B/Mammalian Target of Rapamycin and by Inhibiting MuRF1 and Atrogin-1 Gene Expression in C2C12 Myoblasts.

Sun, KaiJi; Wu, Zhenlong; Ji, Yun; Wu, Guoyao

Sun, KaiJi; Wu, Zhenlong; Ji, Yun; Wu, Guoyao.

Affiliation

Sun K; State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China; and.
Wu Z; State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China; and bio2046@hotmail.com.
Ji Y; State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China; and.
Wu G; State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China; and.

J Nutr ; 146(12): 2461-2467, 2016 Dec.

Article in En | MEDLINE | ID: mdl-27798331

Subject(s)

Glycine/pharmacology; Muscle Proteins/metabolism; Myoblasts/drug effects; Proto-Oncogene Proteins c-akt/metabolism; SKP Cullin F-Box Protein Ligases/metabolism; TOR Serine-Threonine Kinases/metabolism; Tripartite Motif Proteins/metabolism; Ubiquitin-Protein Ligases/metabolism; Animals; Cell Line; Chromones/pharmacology; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Mice; Morpholines/pharmacology; Muscle Proteins/genetics; Myoblasts/metabolism; Proto-Oncogene Proteins c-akt/genetics; SKP Cullin F-Box Protein Ligases/genetics; TOR Serine-Threonine Kinases/genetics; Tripartite Motif Proteins/genetics; Ubiquitin-Protein Ligases/genetics

Key words

AMPK; C2C12; PI3K/Akt; glycine; mTOR; protein turnover

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Collection: 01-internacional Database: MEDLINE Main subject: Myoblasts / Ubiquitin-Protein Ligases / SKP Cullin F-Box Protein Ligases / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases / Tripartite Motif Proteins / Glycine / Muscle Proteins Limits: Animals Language: En Journal: J Nutr Year: 2016 Type: Article

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