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Failure of dihydroartemisinin-piperaquine treatment of uncomplicated Plasmodium falciparum malaria in a traveller coming from Ethiopia.
Gobbi, Federico; Buonfrate, Dora; Menegon, Michela; Lunardi, Gianluigi; Angheben, Andrea; Severini, Carlo; Gori, Stefania; Bisoffi, Zeno.
Affiliation
  • Gobbi F; Centre for Tropical Diseases, Hospital Sacro Cuore-Don Calabria, Via Sempreboni 5, Negrar, 37024, Verona, Italy. federico.gobbi@sacrocuore.it.
  • Buonfrate D; Centre for Tropical Diseases, Hospital Sacro Cuore-Don Calabria, Via Sempreboni 5, Negrar, 37024, Verona, Italy.
  • Menegon M; Department of Infectious, Parasitic and Immunomediated Diseases (MIPI), Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
  • Lunardi G; Centre for Tropical Diseases, Hospital Sacro Cuore-Don Calabria, Via Sempreboni 5, Negrar, 37024, Verona, Italy.
  • Angheben A; Centre for Tropical Diseases, Hospital Sacro Cuore-Don Calabria, Via Sempreboni 5, Negrar, 37024, Verona, Italy.
  • Severini C; Department of Infectious, Parasitic and Immunomediated Diseases (MIPI), Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
  • Gori S; Centre for Tropical Diseases, Hospital Sacro Cuore-Don Calabria, Via Sempreboni 5, Negrar, 37024, Verona, Italy.
  • Bisoffi Z; Centre for Tropical Diseases, Hospital Sacro Cuore-Don Calabria, Via Sempreboni 5, Negrar, 37024, Verona, Italy.
Malar J ; 15(1): 525, 2016 Nov 03.
Article in En | MEDLINE | ID: mdl-27809844
BACKGROUND: Artemisinin combination therapy (ACT) is used worldwide as the first-line treatment against uncomplicated Plasmodium falciparum malaria. Despite the success of ACT in reducing the global burden of malaria, the emerging of resistance to artemisinin threatens its use. CASE REPORT: This report describes the first case of failure of dihydroartemisinin-piperaquine (DHA-PPQ) for the treatment of P. falciparum malaria diagnosed in Europe. It occurred in an Italian tourist returned from Ethiopia. She completely recovered after the DHA-PPQ treatment but 32 days after the end of therapy she had a recrudescence. The retrospective analysis indicated a correct DHA-PPQ absorption and genotyping demonstrated that the same P. falciparum strain was responsible for the both episodes. CONCLUSION: In consideration of the growing number of cases of resistance to ACT, it is important to consider a possible recrudescence, that can manifest also several weeks after treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Malaria, Falciparum / Artemisinins / Overweight / Antimalarials Limits: Adult / Humans Country/Region as subject: Africa / Europa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2016 Type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Malaria, Falciparum / Artemisinins / Overweight / Antimalarials Limits: Adult / Humans Country/Region as subject: Africa / Europa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2016 Type: Article Affiliation country: Italy