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Design and synthesis of water soluble ß-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors.
Wu, Wen-Lian; Burnett, Duane A; Clader, John; Greenlee, William J; Jiang, Qin; Hyde, Lynn A; Del Vecchio, Robert A; Cohen-Williams, Mary E; Song, Lixin; Lee, Julie; Terracina, Giuseppe; Zhang, Qi; Nomeir, Amin; Parker, Eric M; Zhang, Lili.
Affiliation
  • Wu WL; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Burnett DA; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Clader J; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Greenlee WJ; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Jiang Q; Albany Molecular Research, Inc., 26 Corporate Cir, Albany, NY 12212, USA.
  • Hyde LA; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Del Vecchio RA; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Cohen-Williams ME; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Song L; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Lee J; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Terracina G; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Zhang Q; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Nomeir A; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Parker EM; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Zhang L; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett ; 26(23): 5836-5841, 2016 12 01.
Article in En | MEDLINE | ID: mdl-27836402
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Benzopyrans / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States
Fulltext
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Benzopyrans / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States