Intrinsic lens potential of neural retina inhibited by Notch signaling as the cause of lens transdifferentiation.

Iida, Hideaki; Ishii, Yasuo; Kondoh, Hisato

Iida, Hideaki; Ishii, Yasuo; Kondoh, Hisato.

Affiliation

Iida H; Graduate School of Engineering, Kyoto Sangyo University, Kamigamo Motoyama, Kita-ku, Kyoto 603-8555, Japan.
Ishii Y; Faculty of Biosciences, Kyoto Sangyo University, Kamigamo Motoyama, Kita-ku, Kyoto 603-8555, Japan.
Kondoh H; Graduate School of Engineering, Kyoto Sangyo University, Kamigamo Motoyama, Kita-ku, Kyoto 603-8555, Japan; Faculty of Biosciences, Kyoto Sangyo University, Kamigamo Motoyama, Kita-ku, Kyoto 603-8555, Japan. Electronic address: kondohh@cc.kyoto-su.ac.jp.

Dev Biol ; 421(2): 118-125, 2017 Jan 15.

Article in En | MEDLINE | ID: mdl-27845051

Subject(s)

Cell Transdifferentiation; Lens, Crystalline/cytology; Receptors, Notch/metabolism; Retina/cytology; Signal Transduction; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Amyloid Precursor Protein Secretases/metabolism; Animals; Cell Transdifferentiation/drug effects; Cells, Cultured; Chick Embryo; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Developmental/drug effects; Immunoblotting; Lens, Crystalline/drug effects; Models, Biological; Signal Transduction/drug effects; Time Factors; Transcription Factors/genetics; Transcription Factors/metabolism

Key words

DAPT; Lens transdifferentiation; Neural retina; Notch signaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Signal Transduction / Receptors, Notch / Cell Transdifferentiation / Lens, Crystalline Type of study: Prognostic_studies Limits: Animals Language: En Journal: Dev Biol Year: 2017 Type: Article Affiliation country: Japan

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