Drug-target interaction kinetics: underutilized in drug optimization?

Copeland, Robert A

Copeland, Robert A.

Affiliation

Copeland RA; Research & Development, Epizyme, Inc., 400 Technology Square, Cambridge, MA 02139, USA.

Future Med Chem ; 8(18): 2173-2175, 2016 12.

Article in En | MEDLINE | ID: mdl-27845591

Subject(s)

Drug Discovery/methods; Animals; Humans; Kinetics; Models, Biological; Molecular Targeted Therapy; Pharmacokinetics; Pharmacological Phenomena

Key words

drugtarget residence time; kinetics; lead optimization; pharmacodynamics; pharmacokineticpharmacodynamics relationship

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Drug Discovery Limits: Animals / Humans Language: En Journal: Future Med Chem Year: 2016 Type: Article Affiliation country: United States

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