Effect of Post-Translational Amidation on Islet Amyloid Polypeptide Conformational Ensemble: Implications for Its Aggregation Early Steps.

Tran, Linh; Ha-Duong, Tâp

Tran, Linh; Ha-Duong, Tâp.

Affiliation

Tran L; BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France. thi-thuy-linh.tran@u-psud.fr.
Ha-Duong T; BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France. tap.ha-duong@u-psud.fr.

Int J Mol Sci ; 17(11)2016 Nov 14.

Article in En | MEDLINE | ID: mdl-27854243

Subject(s)

Amyloid/chemistry; Islet Amyloid Polypeptide/chemistry; Amides/chemistry; Humans; Kinetics; Molecular Dynamics Simulation; Protein Aggregation, Pathological; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein Structure, Secondary; Thermodynamics

Key words

IAPP; conformational selection mechanism; intrinsically disordered protein; replica exchange molecular dynamics; transient secondary structures

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Islet Amyloid Polypeptide / Amyloid Limits: Humans Language: En Journal: Int J Mol Sci Year: 2016 Type: Article Affiliation country: France

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