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New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis. Practice-based Recommendations.
Harausz, Elizabeth P; Garcia-Prats, Anthony J; Seddon, James A; Schaaf, H Simon; Hesseling, Anneke C; Achar, Jay; Bernheimer, Jonathan; Cruz, Andrea T; D'Ambrosio, Lia; Detjen, Anne; Graham, Stephen M; Hughes, Jennifer; Jonckheere, Sylvie; Marais, Ben J; Migliori, Giovanni Battista; McKenna, Lindsay; Skrahina, Alena; Tadolini, Marina; Wilson, Peyton; Furin, Jennifer.
Affiliation
  • Harausz EP; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland.
  • Garcia-Prats AJ; 2 Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Seddon JA; 3 Centre for International Child Health, Imperial College London, United Kingdom.
  • Schaaf HS; 2 Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Hesseling AC; 2 Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Achar J; 4 Manson Unit, Médecins Sans Frontières, London, United Kingdom.
  • Bernheimer J; 5 Médecins Sans Frontières, Khayelitsha, South Africa.
  • Cruz AT; 6 Baylor College of Medicine, Houston, Texas.
  • D'Ambrosio L; 7 Salvatore Maugeri Foundation, Tradate, Italy.
  • Detjen A; 8 Public Health Consulting Group, Lugano, Switzerland.
  • Graham SM; 9 United Nations Children's Fund, New York, New York.
  • Hughes J; 10 Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
  • Jonckheere S; 5 Médecins Sans Frontières, Khayelitsha, South Africa.
  • Marais BJ; 11 Médecins Sans Frontières, Mumbai, India.
  • Migliori GB; 12 Children's Hospital at Westmead, University of Sydney, Sydney, Australia.
  • McKenna L; 7 Salvatore Maugeri Foundation, Tradate, Italy.
  • Skrahina A; 13 Treatment Action Group, HIV/TB Project, New York, New York.
  • Tadolini M; 14 Republican Research and Practical Centre for Pulmonology and TB, Minsk, Belarus; and.
  • Wilson P; 15 Unit of Infectious Diseases, Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
  • Furin J; 16 Department of Medicine, Boston Children's Hospital, Boston, Massachusetts; and.
Am J Respir Crit Care Med ; 195(10): 1300-1310, 2017 05 15.
Article in En | MEDLINE | ID: mdl-27854508
ABSTRACT
It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the pediatric population. This is despite the fact that these drugs and regimens are associated with improved interim outcomes and acceptable safety profiles in adults. This review fills a gap in the pediatric MDR-TB literature by providing practice-based recommendations for the use of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and the new shorter MDR-TB regimen in children and adolescents.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Multidrug-Resistant / Antitubercular Agents Type of study: Guideline Limits: Adolescent / Child / Humans Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2017 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Multidrug-Resistant / Antitubercular Agents Type of study: Guideline Limits: Adolescent / Child / Humans Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2017 Type: Article