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Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects.
Cossarizza, A; Monti, D; Bersani, F; Paganelli, R; Montagnani, G; Cadossi, R; Cantini, M; Franceschi, C.
Affiliation
  • Cossarizza A; Institute of General Pathology, University of Modena, Italy.
FEBS Lett ; 248(1-2): 141-4, 1989 May 08.
Article in En | MEDLINE | ID: mdl-2785933
ABSTRACT
The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Aged, 80 and over / Lymphocytes / Receptors, Interleukin-2 / Interleukin-2 / Electromagnetic Fields / Electromagnetic Phenomena Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: FEBS Lett Year: 1989 Type: Article Affiliation country: Italy
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Collection: 01-internacional Database: MEDLINE Main subject: Aged, 80 and over / Lymphocytes / Receptors, Interleukin-2 / Interleukin-2 / Electromagnetic Fields / Electromagnetic Phenomena Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: FEBS Lett Year: 1989 Type: Article Affiliation country: Italy