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Ghrelin function in human obesity and type 2 diabetes: a concise review.
Churm, R; Davies, J S; Stephens, J W; Prior, S L.
Affiliation
  • Churm R; Diabetes Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
  • Davies JS; Molecular Neurobiology Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
  • Stephens JW; Diabetes Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
  • Prior SL; Diabetes Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
Obes Rev ; 18(2): 140-148, 2017 02.
Article in En | MEDLINE | ID: mdl-27899023
ABSTRACT
The 28 amino acid hormone, ghrelin, has been found to have various effects on metabolism. This review will focus on the pathways integrated into ghrelin's effect within the hypothalamus, pancreas and adipocytes. The identification of molecules and pathways that regulate ghrelin-mediated lipid retention could establish new mechanisms underlying cellular energy homeostasis. The impact of acyl-ghrelin on glucose metabolism and lipid homeostasis may allow for novel preventative or early intervention therapeutic strategies to treat obesity related type 2 diabetes and associated metabolic dysfunction.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Ghrelin / Obesity Limits: Animals / Humans Language: En Journal: Obes Rev Journal subject: METABOLISMO Year: 2017 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Ghrelin / Obesity Limits: Animals / Humans Language: En Journal: Obes Rev Journal subject: METABOLISMO Year: 2017 Type: Article Affiliation country: United kingdom