Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA.

Vorberg, Raffael; Trapp, Nils; Carreira, Erick M; Müller, Klaus

Vorberg, Raffael; Trapp, Nils; Carreira, Erick M; Müller, Klaus.

Affiliation

Vorberg R; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Trapp N; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Carreira EM; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Müller K; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.

Chemistry ; 23(13): 3126-3138, 2017 Mar 02.

Article in En | MEDLINE | ID: mdl-27976829

Subject(s)

Bridged Bicyclo Compounds/chemistry; Heptanes/chemistry; gamma-Aminobutyric Acid/chemistry; Bridged Bicyclo Compounds/chemical synthesis; Carboxylic Acids/chemical synthesis; Carboxylic Acids/chemistry; Crystallography, X-Ray; Heptanes/chemical synthesis; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Stereoisomerism; gamma-Aminobutyric Acid/chemical synthesis

Key words

GABA; X-ray diffraction; conformation analysis; locked conformation; small ring systems

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bridged Bicyclo Compounds / Gamma-Aminobutyric Acid / Heptanes Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2017 Type: Article Affiliation country: Switzerland

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