Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms.

Blankenstein, K I; Borschewski, A; Labes, R; Paliege, A; Boldt, C; McCormick, J A; Ellison, D H; Bader, M; Bachmann, S; Mutig, K

Blankenstein, K I; Borschewski, A; Labes, R; Paliege, A; Boldt, C; McCormick, J A; Ellison, D H; Bader, M; Bachmann, S; Mutig, K.

Affiliation

Blankenstein KI; Department of Anatomy, Charité University Medicine, Berlin, Germany.
Borschewski A; Department of Anatomy, Charité University Medicine, Berlin, Germany.
Labes R; Department of Anatomy, Charité University Medicine, Berlin, Germany.
Paliege A; Department of Anatomy, Charité University Medicine, Berlin, Germany.
Boldt C; Berlin Institute of Health, Berlin, Germany.
McCormick JA; Department of Anatomy, Charité University Medicine, Berlin, Germany.
Ellison DH; Division of Nephrology and Hypertension, Oregon Health & Science University and Veterans Affairs Medical Center, Portland, Oregon; and.
Bader M; Division of Nephrology and Hypertension, Oregon Health & Science University and Veterans Affairs Medical Center, Portland, Oregon; and.
Bachmann S; Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Mutig K; Department of Anatomy, Charité University Medicine, Berlin, Germany.

Am J Physiol Renal Physiol ; 312(3): F489-F501, 2017 03 01.

Article in En | MEDLINE | ID: mdl-28003191

Subject(s)

Calcineurin Inhibitors/toxicity; Cyclosporine/toxicity; Epithelial Cells/drug effects; Immunosuppressive Agents/toxicity; Kidney Tubules, Distal/drug effects; Loop of Henle/drug effects; Solute Carrier Family 12, Member 1/agonists; Animals; Arginine Vasopressin/pharmacology; Cells, Cultured; Cyclooxygenase 2/metabolism; Epithelial Cells/metabolism; Hypertension/chemically induced; Hypertension/metabolism; Hypertension/physiopathology; Kidney Tubules, Distal/metabolism; Kidney Tubules, Distal/physiopathology; Loop of Henle/metabolism; Loop of Henle/physiopathology; Male; Rats, Brattleboro; Rats, Wistar; Renin/metabolism; Solute Carrier Family 12, Member 1/genetics; Solute Carrier Family 12, Member 1/metabolism; Solute Carrier Family 12, Member 3/agonists; Solute Carrier Family 12, Member 3/genetics; Solute Carrier Family 12, Member 3/metabolism; Time Factors; Water-Electrolyte Balance/drug effects

Key words

hypertension; salt transport; sodium-chloride cotransporter; sodium-potassium-chloride cotransporter; vasopressin

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Epithelial Cells / Solute Carrier Family 12, Member 1 / Calcineurin Inhibitors / Immunosuppressive Agents / Kidney Tubules, Distal / Loop of Henle Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2017 Type: Article Affiliation country: Germany

Fulltext

XML

PubMed Links

Search on Google