Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies.

Sawicki, E; Schellens, J H M; Beijnen, J H; Nuijen, B

Sawicki, E; Schellens, J H M; Beijnen, J H; Nuijen, B.

Affiliation

Sawicki E; a Department of Pharmacy and Pharmacology , Antoni van Leeuwenhoek Hospital/MC Slotervaart , Amsterdam , The Netherlands.
Schellens JH; b Department of Clinical Pharmacology , the Netherlands Cancer Institute , Amsterdam , the Netherlands.
Beijnen JH; c Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology , Utrecht University , Utrecht , the Netherlands.
Nuijen B; a Department of Pharmacy and Pharmacology , Antoni van Leeuwenhoek Hospital/MC Slotervaart , Amsterdam , The Netherlands.

Drug Dev Ind Pharm ; 43(4): 584-594, 2017 Apr.

Article in En | MEDLINE | ID: mdl-28010129

Subject(s)

Acridines/chemistry; Tablets/chemistry; Tetrahydroisoquinolines/chemistry; Acridines/pharmacokinetics; Biological Availability; Chemistry, Pharmaceutical/methods; Crystallization/methods; Drug Stability; Excipients/chemistry; Freeze Drying/methods; Povidone/chemistry; Powders/chemistry; Sodium Dodecyl Sulfate/chemistry; Solubility; Tablets/pharmacokinetics; Technology, Pharmaceutical/methods; Tetrahydroisoquinolines/pharmacokinetics

Key words

Elacridar; GF120918; GG918; P-gp; absorption; brain penetration; dissolution; freeze drying; solid dispersion; spray drying

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tablets / Acridines / Tetrahydroisoquinolines Language: En Journal: Drug Dev Ind Pharm Year: 2017 Type: Article Affiliation country: Netherlands

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