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Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis.
Scalacci, Nicolò; Brown, Alistair K; Pavan, Fernando R; Ribeiro, Camila M; Manetti, Fabrizio; Bhakta, Sanjib; Maitra, Arundhati; Smith, Darren L; Petricci, Elena; Castagnolo, Daniele.
Affiliation
  • Scalacci N; Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London, SE1 9NH, United Kingdom; Northumbria University Newcastle, Department of Applied Sciences, Ellison Building, Ellison Place, NE1 8ST, Newcastle upon Tyne, United Kingdom.
  • Brown AK; School of Medicine, Pharmacy and Health, Durham University, Wolfson Research Institute, Queens Campus, Stockton on Tees, TS17 6BH, United Kingdom.
  • Pavan FR; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil.
  • Ribeiro CM; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil.
  • Manetti F; Dipartimento di Biotecnologie, Chimica e Farmacia, Via A. Moro 2, 53100, Siena, Italy.
  • Bhakta S; Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom.
  • Maitra A; Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom.
  • Smith DL; Northumbria University Newcastle, Department of Applied Sciences, Ellison Building, Ellison Place, NE1 8ST, Newcastle upon Tyne, United Kingdom.
  • Petricci E; Dipartimento di Biotecnologie, Chimica e Farmacia, Via A. Moro 2, 53100, Siena, Italy.
  • Castagnolo D; Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London, SE1 9NH, United Kingdom. Electronic address: daniele.castagnolo@kcl.ac.uk.
Eur J Med Chem ; 127: 147-158, 2017 Feb 15.
Article in En | MEDLINE | ID: mdl-28039773
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioridazine / Drug Design / Drug Resistance, Multiple / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2017 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioridazine / Drug Design / Drug Resistance, Multiple / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2017 Type: Article Affiliation country: United kingdom