Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.

Klima, Martin; Chalupska, Dominika; Rózycki, Bartosz; Humpolickova, Jana; Rezabkova, Lenka; Silhan, Jan; Baumlova, Adriana; Dubankova, Anna; Boura, Evzen

Klima, Martin; Chalupska, Dominika; Rózycki, Bartosz; Humpolickova, Jana; Rezabkova, Lenka; Silhan, Jan; Baumlova, Adriana; Dubankova, Anna; Boura, Evzen.

Affiliation

Klima M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic. Electronic address: klima@uochb.cas.cz.
Chalupska D; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic.
Rózycki B; Institute of Physics, Polish Academy of Sciences, 02-668 Warsaw, Poland.
Humpolickova J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic.
Rezabkova L; Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.
Silhan J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic.
Baumlova A; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic.
Dubankova A; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic.
Boura E; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic. Electronic address: boura@uochb.cas.cz.

Structure ; 25(2): 219-230, 2017 02 07.

Article in En | MEDLINE | ID: mdl-28065508

Subject(s)

Adaptor Proteins, Signal Transducing/chemistry; Host-Pathogen Interactions; Kobuvirus/genetics; Membrane Proteins/chemistry; Unilamellar Liposomes/chemistry; Viral Nonstructural Proteins/chemistry; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Amino Acid Motifs; Binding Sites; Cell Line; Cloning, Molecular; Crystallography, X-Ray; Gene Expression; Humans; Kobuvirus/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Stability; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Viral Nonstructural Proteins/genetics; Viral Nonstructural Proteins/metabolism; Virus Replication/genetics

Key words

3A; ACBD3; Aichivirus; GOLD; Kobuvirus; molecular dynamics simulations; structure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Nonstructural Proteins / Adaptor Proteins, Signal Transducing / Kobuvirus / Unilamellar Liposomes / Host-Pathogen Interactions / Membrane Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2017 Type: Article

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