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Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion.
Ghasemi Falavarjani, Khalil; Iafe, Nicholas A; Hubschman, Jean-Pierre; Tsui, Irena; Sadda, Srinivas R; Sarraf, David.
Affiliation
  • Ghasemi Falavarjani K; Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 2Doheny Eye Institute, University of California Los Angeles, Los Angeles, California, United States 3Eye Research Center, Rassoul Akram Hospital, Iran University
  • Iafe NA; Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.
  • Hubschman JP; Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.
  • Tsui I; Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.
  • Sadda SR; Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 2Doheny Eye Institute, University of California Los Angeles, Los Angeles, California, United States.
  • Sarraf D; Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States 5Greater Los Angeles VA Healthcare Center, Los Angeles, Califo
Invest Ophthalmol Vis Sci ; 58(1): 30-34, 2017 01 01.
Article in En | MEDLINE | ID: mdl-28114569
Purpose: To evaluate the changes in foveal avascular zone (FAZ) area and the retinal capillary density after a single intravitreal anti-VEGF injection for macular edema secondary to diabetic retinopathy or retinal vein occlusion. Methods: In this prospective noncomparative case series, 18 eyes of 15 patients with diabetic macular edema (13 eyes) or macular edema secondary to central retinal vein occlusion (5 eyes) were included. Optical coherence tomography angiography (OCTA) images were obtained, and retinal capillary vessel density and FAZ area were measured in the foveal and parafoveal regions at the level of the superficial (SCP) and deep retinal capillary plexus (DCP) before and at the first visit after intravitreal injection. Results: The mean interval between baseline and follow up OCTA was 32.5 ± 9.4 (range, 21-50) days. Foveal and parafoveal vessel density in the SCP and DCP were not significantly different before and after intravitreal injection (all P > 0.1), nor was FAZ area (P = 0.48 and P = 0.42, respectively). No significant difference was found between eyes with diabetic macular edema and those with retinal vein occlusion with respect to the mean change of vessel density and FAZ area (all P > 0.05). Conclusions: In this pilot study, retinal capillary density and FAZ area remained statistically unchanged in the short-term after a single intravitreal injection of an anti-VEGF agent.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Vein Occlusion / Fluorescein Angiography / Macular Edema / Angiogenesis Inhibitors / Tomography, Optical Coherence / Diabetic Retinopathy / Macula Lutea Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Invest Ophthalmol Vis Sci Year: 2017 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Vein Occlusion / Fluorescein Angiography / Macular Edema / Angiogenesis Inhibitors / Tomography, Optical Coherence / Diabetic Retinopathy / Macula Lutea Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Invest Ophthalmol Vis Sci Year: 2017 Type: Article