Characterization of ß-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Antimicrob Agents Chemother
; 61(4)2017 04.
Article
in En
| MEDLINE
| ID: mdl-28137799
ABSTRACT
Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified ß-d-N4-hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Chikungunya virus
/
Cytidine
Limits:
Animals
/
Humans
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2017
Type:
Article
Affiliation country:
United States