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Characterization of ß-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Ehteshami, Maryam; Tao, Sijia; Zandi, Keivan; Hsiao, Hui-Mien; Jiang, Yong; Hammond, Emily; Amblard, Franck; Russell, Olivia O; Merits, Andres; Schinazi, Raymond F.
Affiliation
  • Ehteshami M; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Tao S; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Zandi K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Hsiao HM; Tropical Infectious Disease Research and Education Center (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Jiang Y; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Hammond E; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Russell OO; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Merits A; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Schinazi RF; Institute of Technology, University of Tartu, Tartu, Estonia.
Antimicrob Agents Chemother ; 61(4)2017 04.
Article in En | MEDLINE | ID: mdl-28137799
ABSTRACT
Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified ß-d-N4-hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Chikungunya virus / Cytidine Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Chikungunya virus / Cytidine Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: United States