Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy.

Fajardo, Carlos Alberto; Guedan, Sonia; Rojas, Luis Alfonso; Moreno, Rafael; Arias-Badia, Marcel; de Sostoa, Jana; June, Carl H; Alemany, Ramon

Fajardo, Carlos Alberto; Guedan, Sonia; Rojas, Luis Alfonso; Moreno, Rafael; Arias-Badia, Marcel; de Sostoa, Jana; June, Carl H; Alemany, Ramon.

Affiliation

Fajardo CA; ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
Guedan S; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Rojas LA; ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
Moreno R; ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
Arias-Badia M; ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
de Sostoa J; ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
June CH; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Alemany R; ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain. ralemany@iconcologia.net.

Cancer Res ; 77(8): 2052-2063, 2017 04 15.

Article in En | MEDLINE | ID: mdl-28143835

Subject(s)

Adenoviridae/immunology; Antibodies, Bispecific/immunology; ErbB Receptors/immunology; Lymphocytes, Tumor-Infiltrating/immunology; Neoplasms/therapy; Oncolytic Virotherapy/methods; T-Lymphocytes/immunology; A549 Cells; Adenoviridae/genetics; Adenoviridae/metabolism; Animals; Antibodies, Bispecific/biosynthesis; Antibodies, Bispecific/genetics; Cell Line, Tumor; Female; HCT116 Cells; HEK293 Cells; Humans; Jurkat Cells; Lymphocyte Activation; Mice; Mice, SCID; Molecular Targeted Therapy/methods; Neoplasms/immunology; Neoplasms/virology; Random Allocation; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Adenoviridae / Lymphocytes, Tumor-Infiltrating / Antibodies, Bispecific / Oncolytic Virotherapy / ErbB Receptors / Neoplasms Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2017 Type: Article Affiliation country: Spain

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