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Transcriptional Addiction in Cancer.
Bradner, James E; Hnisz, Denes; Young, Richard A.
Affiliation
  • Bradner JE; Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.
  • Hnisz D; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
  • Young RA; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu.
Cell ; 168(4): 629-643, 2017 02 09.
Article in En | MEDLINE | ID: mdl-28187285
ABSTRACT
Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms Limits: Animals / Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms Limits: Animals / Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: United States