Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage.

Sun, Bin; Ross, Susan M; Rowley, Sean; Adeleye, Yeyejide; Clewell, Rebecca A

Sun, Bin; Ross, Susan M; Rowley, Sean; Adeleye, Yeyejide; Clewell, Rebecca A.

Affiliation

Sun B; The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, 27709.
Ross SM; ScitoVation, LLC, Research Triangle Park, NC, 27709.
Rowley S; ScitoVation, LLC, Research Triangle Park, NC, 27709.
Adeleye Y; Unilever, Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, United Kingdom.
Clewell RA; ScitoVation, LLC, Research Triangle Park, NC, 27709.

Environ Mol Mutagen ; 58(2): 72-83, 2017 03.

Article in En | MEDLINE | ID: mdl-28195382

Subject(s)

Apoptosis/drug effects; Ataxia Telangiectasia Mutated Proteins/metabolism; DNA Damage; Etoposide/toxicity; Mesylates/toxicity; Tumor Suppressor Protein p53/metabolism; Cell Cycle/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Flow Cytometry; Gene Knockdown Techniques; HCT116 Cells; Humans; Micronucleus Tests; Signal Transduction; Tumor Suppressor Protein p53/genetics

Key words

HCT116; HT1080; genotoxicity; micronucleus; p53 pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Tumor Suppressor Protein p53 / Apoptosis / Mesylates / Etoposide / Ataxia Telangiectasia Mutated Proteins Limits: Humans Language: En Journal: Environ Mol Mutagen Journal subject: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Year: 2017 Type: Article

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