Comparison of genetic characteristics in the evolution of Norovirus GII.4 and GII.17.
J Med Virol
; 89(8): 1480-1484, 2017 08.
Article
in En
| MEDLINE
| ID: mdl-28198556
ABSTRACT
The genetic characteristics of Norovirus GII.17 were evaluated. Phylogenetic analysis and comparisons of amino acid (Aa) substitutions and nonsynonymous (NS) substitutions/site/year were performed. The complete VP1 sequence of Tokyo/27-3/1976 clustered independently with GII.P17_GII.17 strains. Aa substitutions were mainly accumulated in the P2 domain. NS substitutions/site/year for Tokyo/27-3/1976 compared to Kawasaki323/2014 and Kawasaki308/2015 were 0.57 × 10-3 and 0.78 × 10-3 , respectively; for GII.4 Sydney/NSW0514/2012 compared to CHDC2094/1974 and CHDC5191/1974 were 0.93 × 10-3 and 1.06 × 10-3 , respectively. These findings imply that evolutionary diversity in the VP1 of GII.17 might be strictly constrained in contrast to that of GII.4.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Evolution, Molecular
/
Norovirus
/
Genotype
Limits:
Humans
Language:
En
Journal:
J Med Virol
Year:
2017
Type:
Article
Affiliation country:
Japan