Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor.

Li, Li; Ng, Nelson Ka Lam; Koon, Alex Chun; Chan, Ho Yin Edwin

Li, Li; Ng, Nelson Ka Lam; Koon, Alex Chun; Chan, Ho Yin Edwin.

Affiliation

Li L; From the Laboratory of Drosophila Research.
Ng NK; Biochemistry Program.
Koon AC; From the Laboratory of Drosophila Research.
Chan HY; Biochemistry Program.

J Biol Chem ; 292(14): 5784-5800, 2017 04 07.

Article in En | MEDLINE | ID: mdl-28246169

Subject(s)

Nuclear Export Signals; Peptide Elongation Factor 1/metabolism; Peptides/metabolism; Trinucleotide Repeat Expansion; HEK293 Cells; Humans; Hypoventilation/congenital; Hypoventilation/genetics; Hypoventilation/metabolism; Muscular Dystrophy, Oculopharyngeal/genetics; Muscular Dystrophy, Oculopharyngeal/metabolism; Peptide Elongation Factor 1/genetics; Protein Transport/genetics; Sleep Apnea, Central/genetics; Sleep Apnea, Central/metabolism

Key words

Drosophila genetics; eEF1A; gene transcription; genetic disease; protein export; protein-protein interaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Trinucleotide Repeat Expansion / Peptide Elongation Factor 1 / Nuclear Export Signals Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2017 Type: Article

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