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Common coding variant in SERPINA1 increases the risk for large artery stroke.
Malik, Rainer; Dau, Therese; Gonik, Maria; Sivakumar, Anirudh; Deredge, Daniel J; Edeleva, Evgeniia V; Götzfried, Jessica; van der Laan, Sander W; Pasterkamp, Gerard; Beaufort, Nathalie; Seixas, Susana; Bevan, Steve; Lincz, Lisa F; Holliday, Elizabeth G; Burgess, Annette I; Rannikmäe, Kristiina; Minnerup, Jens; Kriebel, Jennifer; Waldenberger, Melanie; Müller-Nurasyid, Martina; Lichtner, Peter; Saleheen, Danish; Rothwell, Peter M; Levi, Christopher; Attia, John; Sudlow, Cathie L M; Braun, Dieter; Markus, Hugh S; Wintrode, Patrick L; Berger, Klaus; Jenne, Dieter E; Dichgans, Martin.
Affiliation
  • Malik R; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich 81377, Germany.
  • Dau T; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, University Hospital, Ludwig Maximilians University and Helmholtz Zentrum München, German Center for Lung Research, Munich 81377, Germany.
  • Gonik M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich 81377, Germany.
  • Sivakumar A; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.
  • Deredge DJ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.
  • Edeleva EV; Systems Biophysics, Physics Department, Nanosystems Initiative Munich and Center for NanoScience, Ludwig-Maximilians-Universität Munich, Munich 80799, Germany.
  • Götzfried J; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, University Hospital, Ludwig Maximilians University and Helmholtz Zentrum München, German Center for Lung Research, Munich 81377, Germany.
  • van der Laan SW; Laboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
  • Pasterkamp G; Laboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
  • Beaufort N; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich 81377, Germany.
  • Seixas S; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
  • Bevan S; Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
  • Lincz LF; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
  • Holliday EG; Public Health Research Program, Hunter Medical Research Institute, Newcastle, 2305, Australia.
  • Burgess AI; Public Health Research Program, Hunter Medical Research Institute, Newcastle, 2305, Australia.
  • Rannikmäe K; Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.
  • Minnerup J; Division of Clinical Neurosciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
  • Kriebel J; Institute of Epidemiology and Social Medicine, University of Münster, Muenster 48149, Germany.
  • Waldenberger M; Department of Neurology, University of Münster, Muenster 48149, Germany.
  • Müller-Nurasyid M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg 85764, Germany.
  • Lichtner P; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg 85764, Germany.
  • Saleheen D; Institut für Genetische Epidemiologie, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg 85764, Germany.
  • Rothwell PM; Institut für Humangenetik, Technische Universität München, Munich 85764, Germany.
  • Levi C; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
  • Sudlow CL; Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.
  • Braun D; Public Health Research Program, Hunter Medical Research Institute, Newcastle, 2305, Australia.
  • Markus HS; Public Health Research Program, Hunter Medical Research Institute, Newcastle, 2305, Australia.
  • Wintrode PL; Division of Clinical Neurosciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
  • Berger K; Systems Biophysics, Physics Department, Nanosystems Initiative Munich and Center for NanoScience, Ludwig-Maximilians-Universität Munich, Munich 80799, Germany.
  • Jenne DE; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
  • Dichgans M; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.
Proc Natl Acad Sci U S A ; 114(14): 3613-3618, 2017 04 04.
Article in En | MEDLINE | ID: mdl-28265093
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Alpha 1-Antitrypsin / Stroke / Polymorphism, Single Nucleotide / Plaque, Atherosclerotic / Histone Deacetylases Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Alpha 1-Antitrypsin / Stroke / Polymorphism, Single Nucleotide / Plaque, Atherosclerotic / Histone Deacetylases Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Type: Article Affiliation country: Germany