Short article: Evaluation of O6-methylguanine-DNA methyltransferase as a predicting factor of response to temozolomide-based chemotherapy in well-differentiated metastatic pancreatic neuroendocrine tumors.

Girot, Paul; Dumars, Clotilde; Mosnier, Jean-François; Muzellec, Léa; Senellart, Hélène; Foubert, Fanny; Caroli-Bosc, François-Xavier; Cauchin, Estelle; Regenet, Nicolas; Matysiak-Budnik, Tamara; Touchefeu, Yann

Girot, Paul; Dumars, Clotilde; Mosnier, Jean-François; Muzellec, Léa; Senellart, Hélène; Foubert, Fanny; Caroli-Bosc, François-Xavier; Cauchin, Estelle; Regenet, Nicolas; Matysiak-Budnik, Tamara; Touchefeu, Yann.

Affiliation

Girot P; aIMAD, Department of Gastroenterology & Digestive Oncology Departments of bPathology cSurgery, Nantes University Hospital dINSERM, U913 eINSERM, U1232, University of Nantes fIntegrated Center for Oncology, Centre René Gauducheau, Saint Herblain gDepartment of Gastroenterology & Digestive Oncology, CHU d'Angers, Angers, France.

Eur J Gastroenterol Hepatol ; 29(7): 826-830, 2017 Jul.

Article in En | MEDLINE | ID: mdl-28328619

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biomarkers, Tumor/analysis; Cell Differentiation; DNA Modification Methylases/analysis; DNA Repair Enzymes/analysis; Dacarbazine/analogs & derivatives; Neuroendocrine Tumors/drug therapy; Pancreatic Neoplasms/drug therapy; Tumor Suppressor Proteins/analysis; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Biomarkers, Tumor/genetics; DNA Methylation; DNA Modification Methylases/genetics; DNA Repair Enzymes/genetics; Dacarbazine/adverse effects; Dacarbazine/therapeutic use; Disease Progression; Disease-Free Survival; Female; France; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neuroendocrine Tumors/enzymology; Neuroendocrine Tumors/mortality; Neuroendocrine Tumors/pathology; Pancreatic Neoplasms/enzymology; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology; Patient Selection; Polymerase Chain Reaction; Precision Medicine; Predictive Value of Tests; Promoter Regions, Genetic; Retrospective Studies; Temozolomide; Time Factors; Treatment Outcome; Tumor Suppressor Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / DNA Modification Methylases / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Cell Differentiation / Neuroendocrine Tumors / Tumor Suppressor Proteins / Dacarbazine / DNA Repair Enzymes Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged80 Country/Region as subject: Europa Language: En Journal: Eur J Gastroenterol Hepatol Journal subject: GASTROENTEROLOGIA Year: 2017 Type: Article Affiliation country: France

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