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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.
Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine; Yizhak, Keren; Neftel, Cyril; Filbin, Mariella G; Hovestadt, Volker; Escalante, Leah E; Shaw, McKenzie L; Rodman, Christopher; Gillespie, Shawn M; Dionne, Danielle; Luo, Christina C; Ravichandran, Hiranmayi; Mylvaganam, Ravindra; Mount, Christopher; Onozato, Maristela L; Nahed, Brian V; Wakimoto, Hiroaki; Curry, William T; Iafrate, A John; Rivera, Miguel N; Frosch, Matthew P; Golub, Todd R; Brastianos, Priscilla K; Getz, Gad; Patel, Anoop P; Monje, Michelle; Cahill, Daniel P; Rozenblatt-Rosen, Orit; Louis, David N; Bernstein, Bradley E; Regev, Aviv; Suvà, Mario L.
Affiliation
  • Venteicher AS; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Tirosh I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Hebert C; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Yizhak K; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. suva.mario@mgh.harvard.edu aregev@broadinstitute.org tirosh@broadinstitute.org.
  • Neftel C; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Filbin MG; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Hovestadt V; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Escalante LE; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Shaw ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Rodman C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Gillespie SM; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
  • Dionne D; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Luo CC; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Ravichandran H; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Cancer Center, Boston, MA 02215, USA.
  • Mylvaganam R; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Mount C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Onozato ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Nahed BV; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Wakimoto H; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Curry WT; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Iafrate AJ; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Rivera MN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Frosch MP; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Golub TR; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Brastianos PK; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Getz G; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Patel AP; Departments of Neurology, Neurosurgery, Pediatrics and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Monje M; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Cahill DP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Rozenblatt-Rosen O; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Louis DN; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Regev A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Suvà ML; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Science ; 355(6332)2017 03 31.
Article in En | MEDLINE | ID: mdl-28360267

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Tumor Microenvironment / Glioma / Isocitrate Dehydrogenase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Science Year: 2017 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Tumor Microenvironment / Glioma / Isocitrate Dehydrogenase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Science Year: 2017 Type: Article Affiliation country: United States