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Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy.
El Beaino, Marc; Araujo, Dejka M; Lazar, Alexander J; Lin, Patrick P.
Affiliation
  • El Beaino M; Department of Orthopaedic Oncology - Unit 1448, MD Anderson Cancer Center, Houston, TX, USA.
  • Araujo DM; Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
  • Lazar AJ; Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA.
  • Lin PP; Department of Orthopaedic Oncology - Unit 1448, MD Anderson Cancer Center, Houston, TX, USA. plin@mdanderson.org.
Ann Surg Oncol ; 24(8): 2145-2154, 2017 Aug.
Article in En | MEDLINE | ID: mdl-28397189
ABSTRACT
Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Sarcoma, Synovial / Molecular Targeted Therapy Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Ann Surg Oncol Journal subject: NEOPLASIAS Year: 2017 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Sarcoma, Synovial / Molecular Targeted Therapy Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Ann Surg Oncol Journal subject: NEOPLASIAS Year: 2017 Type: Article Affiliation country: United States