CRISPR/Cas9-mediated deletion of lncRNA Gm26878 in the distant Foxf1 enhancer region.

Szafranski, Przemyslaw; Karolak, Justyna A; Lanza, Denise; Gajecka, Marzena; Heaney, Jason; Stankiewicz, Pawel

Szafranski, Przemyslaw; Karolak, Justyna A; Lanza, Denise; Gajecka, Marzena; Heaney, Jason; Stankiewicz, Pawel.

Affiliation

Szafranski P; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Karolak JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Lanza D; Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.
Gajecka M; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Heaney J; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Stankiewicz P; Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.

Mamm Genome ; 28(7-8): 275-282, 2017 Aug.

Article in En | MEDLINE | ID: mdl-28405742

Subject(s)

CRISPR-Cas Systems; Enhancer Elements, Genetic; Forkhead Transcription Factors/genetics; Gene Editing; RNA, Long Noncoding/genetics; Sequence Deletion; Alleles; Animals; Binding Sites; Gene Dosage; Gene Expression; Gene Knockout Techniques; Genotype; Humans; Mice; Mice, Knockout; Mutagenesis; Persistent Fetal Circulation Syndrome/genetics; Protein Binding

Key words

Deletion Allele; Genome Editing; Transcription Factor Binding Site; UCSC Genome Browser; lncRNA Gene

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enhancer Elements, Genetic / Sequence Deletion / Forkhead Transcription Factors / RNA, Long Noncoding / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mamm Genome Journal subject: GENETICA Year: 2017 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google