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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
Schludi, Martin H; Becker, Lore; Garrett, Lillian; Gendron, Tania F; Zhou, Qihui; Schreiber, Franziska; Popper, Bastian; Dimou, Leda; Strom, Tim M; Winkelmann, Juliane; von Thaden, Anne; Rentzsch, Kristin; May, Stephanie; Michaelsen, Meike; Schwenk, Benjamin M; Tan, Jing; Schoser, Benedikt; Dieterich, Marianne; Petrucelli, Leonard; Hölter, Sabine M; Wurst, Wolfgang; Fuchs, Helmut; Gailus-Durner, Valerie; de Angelis, Martin Hrabe; Klopstock, Thomas; Arzberger, Thomas; Edbauer, Dieter.
Affiliation
  • Schludi MH; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Becker L; Munich Cluster for System Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Garrett L; German Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
  • Gendron TF; German Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
  • Zhou Q; Institute of Developmental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
  • Schreiber F; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
  • Popper B; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Dimou L; Munich Cluster for System Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Strom TM; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Winkelmann J; Department of Anatomy and Cell Biology, Biomedical Center, Ludwig-Maximilians-University Munich, Großhaderner Str. 9, 82152, Planegg-Martinsried, Germany.
  • von Thaden A; Physiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Großhaderner Str. 9, 82152, Planegg-Martinsried, Germany.
  • Rentzsch K; Molecular and Translational Neuroscience, Department of Neurology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
  • May S; Institut für Humangenetik, Helmholtz Zentrum München, 85764, Munich, Germany.
  • Michaelsen M; Munich Cluster for System Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Schwenk BM; Institut für Neurogenomik, Helmholtz Zentrum München, 85764, Munich, Germany.
  • Tan J; Neurologische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany.
  • Schoser B; Institut für Humangenetik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany.
  • Dieterich M; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Petrucelli L; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Hölter SM; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Wurst W; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Fuchs H; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Gailus-Durner V; Institut für Neurogenomik, Helmholtz Zentrum München, 85764, Munich, Germany.
  • de Angelis MH; Department of Neurology, Friedrich-Baur-Institute, Klinikum der Ludwig-Maximilians-Universität München, Ziemssenstr. 1a, 80336, Munich, Germany.
  • Klopstock T; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Arzberger T; Munich Cluster for System Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377, Munich, Germany.
  • Edbauer D; Department of Neurology, Friedrich-Baur-Institute, Klinikum der Ludwig-Maximilians-Universität München, Ziemssenstr. 1a, 80336, Munich, Germany.
Acta Neuropathol ; 134(2): 241-254, 2017 08.
Article in En | MEDLINE | ID: mdl-28409281
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Inclusion Bodies / Central Nervous System Diseases / DNA Repeat Expansion / C9orf72 Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Neuropathol Year: 2017 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Inclusion Bodies / Central Nervous System Diseases / DNA Repeat Expansion / C9orf72 Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Neuropathol Year: 2017 Type: Article Affiliation country: Germany