Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).

Sala-Rabanal, Monica; Yurtsever, Zeynep; Berry, Kayla N; Nichols, Colin G; Brett, Tom J

Sala-Rabanal, Monica; Yurtsever, Zeynep; Berry, Kayla N; Nichols, Colin G; Brett, Tom J.

Affiliation

Sala-Rabanal M; From the Center for the Investigation of Membrane Excitability Diseases.
Yurtsever Z; Department of Cell Biology and Physiology.
Berry KN; Biochemistry Program.
Nichols CG; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine.
Brett TJ; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine.

J Biol Chem ; 292(22): 9164-9174, 2017 06 02.

Article in En | MEDLINE | ID: mdl-28420732

Subject(s)

Chloride Channels/metabolism; Magnesium/metabolism; Mutation, Missense; Neoplasm Proteins/metabolism; Amino Acid Substitution; Anoctamin-1; Cell Line; Chloride Channels/genetics; Humans; Neoplasm Proteins/genetics; Protein Domains; Protein Stability

Key words

TMEM16A; calcium-activated chloride channel; calcium-activated chloride channel regulator 1 (CLCA1); chloride channel; cystic fibrosis; drug development; magnesium; metal ion-dependent adhesion site (MIDAS); protein-protein interaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chloride Channels / Mutation, Missense / Magnesium / Neoplasm Proteins Limits: Humans Language: En Journal: J Biol Chem Year: 2017 Type: Article

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