Resistance to RadLV-induced leukemia: non-participation of splenic natural killer cells.
Leukemia
; 2(8): 551-3, 1988 Aug.
Article
in En
| MEDLINE
| ID: mdl-2842550
ABSTRACT
The phenotypic expression of genetically determined resistance to radiation leukemia virus (RadLV)-induced leukemia in mice has been shown to reside in the bone marrow. Because the bone marrow contains precursors of natural killer (NK) cells, known to play a role in retrovirally induced infections, and because these cells have been suggested as participating in resistance to radiation-induced leukemia, it was pertinent to establish whether their levels differed in strains of mice susceptible and resistant to leukemia. We therefore tested splenic NK cell levels in C57BL/Ka (susceptible) and B10.A(5R) (resistant) mice before viral inoculation, immediately after viral inoculation, and throughout the preleukemic period and showed that they were not different. This indicates that splenic NK cell levels have no bearing on the resistance to RadLV-induced leukemia and that other immune or non-immune mechanisms must be sought.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spleen
/
Killer Cells, Natural
/
Leukemia, Experimental
/
Leukemia, Radiation-Induced
Limits:
Animals
Language:
En
Journal:
Leukemia
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
1988
Type:
Article
Affiliation country:
Canada