Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.

Li, Mavis Jiarong; Nath, Abhinav; Atkins, William M

Li, Mavis Jiarong; Nath, Abhinav; Atkins, William M.

Affiliation

Li MJ; Department of Medicinal Chemistry, University of Washington , Box 357610, Seattle, Washington 98195-7610, United States.
Nath A; Department of Medicinal Chemistry, University of Washington , Box 357610, Seattle, Washington 98195-7610, United States.
Atkins WM; Department of Medicinal Chemistry, University of Washington , Box 357610, Seattle, Washington 98195-7610, United States.

Biochemistry ; 56(19): 2506-2517, 2017 05 16.

Article in En | MEDLINE | ID: mdl-28441502

Subject(s)

ATP Binding Cassette Transporter, Subfamily B/metabolism; Lipid Bilayers/chemistry; Models, Molecular; ATP Binding Cassette Transporter, Subfamily B/chemistry; ATP Binding Cassette Transporter, Subfamily B/genetics; Adenosine Triphosphate/metabolism; Animals; Binding Sites; Binding, Competitive; Biological Transport; Boron Compounds/metabolism; Dimyristoylphosphatidylcholine/chemistry; Fluorescent Dyes/metabolism; Humans; Hydrolysis; Kinetics; Ligands; Mice; Nanostructures/chemistry; Protein Conformation; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Taxoids/metabolism; Verapamil/analogs & derivatives; Verapamil/metabolism; Vinblastine/analogs & derivatives; Vinblastine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / ATP Binding Cassette Transporter, Subfamily B / Lipid Bilayers Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2017 Type: Article Affiliation country: United States

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