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Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer.
Chen, Ina; Mathews-Greiner, Lesley; Li, Dandan; Abisoye-Ogunniyan, Abisola; Ray, Satyajit; Bian, Yansong; Shukla, Vivek; Zhang, Xiaohu; Guha, Raj; Thomas, Craig; Gryder, Berkley; Zacharia, Athina; Beane, Joal D; Ravichandran, Sarangan; Ferrer, Marc; Rudloff, Udo.
Affiliation
  • Chen I; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes for Health, CCR 4 West/4-3740, 10 Center Drive, Bethesda, MD, 20892-0001, USA.
  • Mathews-Greiner L; Washington University School of Medicine, St. Louis, KY, USA.
  • Li D; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Abisoye-Ogunniyan A; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes for Health, CCR 4 West/4-3740, 10 Center Drive, Bethesda, MD, 20892-0001, USA.
  • Ray S; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes for Health, CCR 4 West/4-3740, 10 Center Drive, Bethesda, MD, 20892-0001, USA.
  • Bian Y; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL, USA.
  • Shukla V; Surgery Branch, NCI, NIH, Bethesda, MD, USA.
  • Zhang X; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes for Health, CCR 4 West/4-3740, 10 Center Drive, Bethesda, MD, 20892-0001, USA.
  • Guha R; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes for Health, CCR 4 West/4-3740, 10 Center Drive, Bethesda, MD, 20892-0001, USA.
  • Thomas C; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Gryder B; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Zacharia A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Beane JD; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
  • Ravichandran S; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes for Health, CCR 4 West/4-3740, 10 Center Drive, Bethesda, MD, 20892-0001, USA.
  • Ferrer M; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Rudloff U; Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA.
J Transl Med ; 15(1): 92, 2017 05 01.
Article in En | MEDLINE | ID: mdl-28460635
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Cadherins / Gene Expression Profiling / Drug Evaluation, Preclinical / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Adult / Female / Humans / Male Language: En Journal: J Transl Med Year: 2017 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Cadherins / Gene Expression Profiling / Drug Evaluation, Preclinical / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Adult / Female / Humans / Male Language: En Journal: J Transl Med Year: 2017 Type: Article Affiliation country: United States