Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP<sub>swe</sub>/PS1<sub>dE9</sub> transgenic mice: Effect of long-term treatment with paroxetine.

Olesen, Louise Ørum; Sivasaravanaparan, Mithula; Severino, Maurizio; Babcock, Alicia A; Bouzinova, Elena V; West, Mark J; Wiborg, Ove; Finsen, Bente

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP_swe/PS1_dE9 transgenic mice: Effect of long-term treatment with paroxetine.

Olesen, Louise Ørum; Sivasaravanaparan, Mithula; Severino, Maurizio; Babcock, Alicia A; Bouzinova, Elena V; West, Mark J; Wiborg, Ove; Finsen, Bente.

Affiliation

Olesen LØ; Department of Clinical Medicine, Aarhus University, Denmark.
Sivasaravanaparan M; Department of Neurobiological Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark.
Severino M; Department of Neurobiological Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark.
Babcock AA; Department of Neurobiological Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark.
Bouzinova EV; Department of Clinical Medicine, Aarhus University, Denmark.
West MJ; Department of Biomedicine, Health, Aarhus University, Denmark.
Wiborg O; Department of Clinical Medicine, Aarhus University, Denmark.
Finsen B; Department of Neurobiological Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark. Electronic address: bfinsen@health.sdu.dk.

Neurobiol Dis ; 104: 50-60, 2017 Aug.

Article in En | MEDLINE | ID: mdl-28461249

Subject(s)

Aging/pathology; Alzheimer Disease/pathology; Dentate Gyrus/pathology; Neural Stem Cells/pathology; Neurons/pathology; Aging/genetics; Alzheimer Disease/drug therapy; Alzheimer Disease/genetics; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/genetics; Animals; Bromodeoxyuridine/metabolism; Cytochrome P-450 CYP2D6 Inhibitors/therapeutic use; Dentate Gyrus/drug effects; Disease Models, Animal; Doublecortin Domain Proteins; Exploratory Behavior/drug effects; Maze Learning/drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins/metabolism; Mutation/genetics; Neural Stem Cells/drug effects; Neural Stem Cells/metabolism; Neurogenesis/drug effects; Neurogenesis/physiology; Neurons/drug effects; Neurons/metabolism; Neuropeptides/metabolism; Paroxetine/therapeutic use; Presenilin-1/genetics

Key words

APP/PS1 mice; Amyloid plaque load; Granule cells; Hippocampus; Neurogenesis; Paroxetine; SSRI; Spontaneous alternation behaviour

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Dentate Gyrus / Neural Stem Cells / Alzheimer Disease / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2017 Type: Article Affiliation country: Denmark

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