Radiosynthesis and evaluation of IGF1R PET ligand [<sup>11</sup>C]GSK1838705A.

Solingapuram Sai, Kiran Kumar; Prabhakaran, Jaya; Sattiraju, Anirudh; Mann, J John; Mintz, Akiva; Kumar, J S Dileep

Radiosynthesis and evaluation of IGF1R PET ligand [¹¹C]GSK1838705A.

Solingapuram Sai, Kiran Kumar; Prabhakaran, Jaya; Sattiraju, Anirudh; Mann, J John; Mintz, Akiva; Kumar, J S Dileep.

Affiliation

Solingapuram Sai KK; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Prabhakaran J; Department of Psychiatry, Columbia University Medical Center, New York, USA; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA.
Sattiraju A; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Mann JJ; Department of Psychiatry, Columbia University Medical Center, New York, USA; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA.
Mintz A; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kumar JSD; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA. Electronic address: kumardi@nyspi.columbia.edu.

Bioorg Med Chem Lett ; 27(13): 2895-2897, 2017 07 01.

Article in En | MEDLINE | ID: mdl-28479199

Subject(s)

Brain Neoplasms/diagnostic imaging; Glioblastoma/diagnostic imaging; Positron-Emission Tomography; Pyrimidines/chemical synthesis; Pyrimidines/metabolism; Pyrroles/chemical synthesis; Pyrroles/metabolism; Radioligand Assay; Receptors, Somatomedin/metabolism; Animals; Blood-Brain Barrier/diagnostic imaging; Brain/metabolism; Carbon Radioisotopes; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; Protein Binding; Pyrimidines/analysis; Pyrimidines/isolation & purification; Pyrroles/analysis; Pyrroles/isolation & purification; Receptor, IGF Type 1; Structure-Activity Relationship; Substrate Specificity

Key words

Growth factor; IGF1R; Micropet; Radiotracer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Radioligand Assay / Brain Neoplasms / Receptors, Somatomedin / Glioblastoma / Positron-Emission Tomography Type of study: Evaluation_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Type: Article Affiliation country: United States

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