Effect of sodium nitrite on renal function and sodium and water excretion and brachial and central blood pressure in healthy subjects: a dose-response study.

Rosenbaek, Jeppe Bakkestroem; Al Therwani, Safa; Jensen, Janni Majgaard; Mose, Frank Holden; Wandall-Frostholm, Christine; Pedersen, Erling Bjerregaard; Bech, Jesper Noergaard

Rosenbaek, Jeppe Bakkestroem; Al Therwani, Safa; Jensen, Janni Majgaard; Mose, Frank Holden; Wandall-Frostholm, Christine; Pedersen, Erling Bjerregaard; Bech, Jesper Noergaard.

Affiliation

Rosenbaek JB; University Clinic in Nephrology and Hypertension, Regional Hospital West Jutland and Aarhus University, Aarhus, Denmark; and jepros@rm.dk.
Al Therwani S; University Clinic in Nephrology and Hypertension, Regional Hospital West Jutland and Aarhus University, Aarhus, Denmark; and.
Jensen JM; University Clinic in Nephrology and Hypertension, Regional Hospital West Jutland and Aarhus University, Aarhus, Denmark; and.
Mose FH; University Clinic in Nephrology and Hypertension, Regional Hospital West Jutland and Aarhus University, Aarhus, Denmark; and.
Wandall-Frostholm C; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
Pedersen EB; University Clinic in Nephrology and Hypertension, Regional Hospital West Jutland and Aarhus University, Aarhus, Denmark; and.
Bech JN; University Clinic in Nephrology and Hypertension, Regional Hospital West Jutland and Aarhus University, Aarhus, Denmark; and.

Am J Physiol Renal Physiol ; 313(2): F378-F387, 2017 Aug 01.

Article in En | MEDLINE | ID: mdl-28490529

Subject(s)

Arterial Pressure/drug effects; Brachial Artery/drug effects; Glomerular Filtration Rate/drug effects; Kidney/drug effects; Natriuresis/drug effects; Natriuretic Agents/administration & dosage; Nitric Oxide Donors/administration & dosage; Sodium Nitrite/administration & dosage; Urination/drug effects; Vasodilator Agents/administration & dosage; Adult; Aquaporin 2/metabolism; Biomarkers/blood; Cross-Over Studies; Cyclic GMP/metabolism; Dose-Response Relationship, Drug; Epithelial Sodium Channels/metabolism; Female; Healthy Volunteers; Humans; Kidney/metabolism; Male; Natriuretic Agents/metabolism; Nitrates/metabolism; Nitric Oxide/metabolism; Nitric Oxide Donors/metabolism; Nitrites/metabolism; Renin-Angiotensin System/drug effects; Single-Blind Method; Sodium Nitrite/metabolism; Time Factors; Urodynamics/drug effects; Vasodilator Agents/metabolism; Young Adult

Key words

aquaresis; central blood pressure; natriuresis; sodium nitrite; vasoactive hormones

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium Nitrite / Urination / Vasodilator Agents / Brachial Artery / Nitric Oxide Donors / Natriuretic Agents / Arterial Pressure / Glomerular Filtration Rate / Kidney / Natriuresis Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2017 Type: Article

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