An Atomic Structure of the Human Spliceosome.

Zhang, Xiaofeng; Yan, Chuangye; Hang, Jing; Finci, Lorenzo I; Lei, Jianlin; Shi, Yigong

Zhang, Xiaofeng; Yan, Chuangye; Hang, Jing; Finci, Lorenzo I; Lei, Jianlin; Shi, Yigong.

Affiliation

Zhang X; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yan C; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: yancy05@mails.tsinghua.edu.cn.
Hang J; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Finci LI; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Lei J; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, T
Shi Y; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: shi-lab@tsinghua.edu.cn.

Cell ; 169(5): 918-929.e14, 2017 May 18.

Article in En | MEDLINE | ID: mdl-28502770

Subject(s)

RNA Precursors/metabolism; Spliceosomes/chemistry; Spliceosomes/ultrastructure; Base Sequence; Cryoelectron Microscopy; DEAD-box RNA Helicases/metabolism; Exons; Humans; Introns; Models, Molecular; RNA Splicing; RNA Splicing Factors/metabolism; RNA-Binding Proteins/metabolism; Saccharomyces cerevisiae/chemistry; Spliceosomes/metabolism

Key words

C(∗) complex; EJC; atomic structure; cryo-EM; exon junction complex; exon ligation; human spliceosome; pre-mRNA splicing; step 2 factors; step II activated spliceosome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Precursors / Spliceosomes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: China

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