Generation of radical form of dipyridamole at illumination of photosynthetic reaction centers of Rb. sphaeroides.
Dokl Biochem Biophys
; 473(1): 118-121, 2017 Mar.
Article
in En
| MEDLINE
| ID: mdl-28510131
ABSTRACT
The study of the effect of vasodilator, antiplatelet agent, and inhibitor P-glycoprotein dipyridamole (DIP) on the functioning of the transmembrane protein of the reaction center (RC) of Rb. sphaeroides showed that the activation of RC by constant light generates the DIP radical cation, which significantly affects the kinetics of recombination of charges divided between photoactive bacteriochlorophyll and quinone acceptors. Thus, the antioxidant properties of DIP may affect the functional activity of membrane proteins, and this apparently should be taken into account in the studies of the mechanisms of therapeutic action of this drug.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhodobacter sphaeroides
/
Photosynthetic Reaction Center Complex Proteins
/
Dipyridamole
/
Light
Language:
En
Journal:
Dokl Biochem Biophys
Journal subject:
BIOFISICA
/
BIOQUIMICA
Year:
2017
Type:
Article
Affiliation country:
RUSSIA