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HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
Tharkar-Promod, S; Johnson, D P; Bennett, S E; Dennis, E M; Banowsky, B G; Jones, S S; Shearstone, J R; Quayle, S N; Min, C; Jarpe, M; Mosbruger, T; Pomicter, A D; Miles, R R; Chen, W Y; Bhalla, K N; Zweidler-McKay, P A; Shrieve, D C; Deininger, M W; Chandrasekharan, M B; Bhaskara, S.
Affiliation
  • Tharkar-Promod S; Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Johnson DP; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Bennett SE; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Dennis EM; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Banowsky BG; Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Jones SS; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Shearstone JR; Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Quayle SN; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Min C; Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Jarpe M; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Mosbruger T; Acetylon Pharmaceuticals Inc., Boston, MA, USA.
  • Pomicter AD; Regenacy Pharmaceuticals Inc., Boston, MA, USA.
  • Miles RR; Acetylon Pharmaceuticals Inc., Boston, MA, USA.
  • Chen WY; Acetylon Pharmaceuticals Inc., Boston, MA, USA.
  • Bhalla KN; Acetylon Pharmaceuticals Inc., Boston, MA, USA.
  • Zweidler-McKay PA; Regenacy Pharmaceuticals Inc., Boston, MA, USA.
  • Shrieve DC; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Deininger MW; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Chandrasekharan MB; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Bhaskara S; Department of Cancer Biology, City of Hope National Medical Center, Duarte, CA, USA.
Leukemia ; 32(1): 49-60, 2018 01.
Article in En | MEDLINE | ID: mdl-28579617
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Philadelphia Chromosome / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Combined Chemotherapy Protocols / Fusion Proteins, bcr-abl / DNA Repair / Histone Deacetylase 1 / Histone Deacetylase 2 Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2018 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Philadelphia Chromosome / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Combined Chemotherapy Protocols / Fusion Proteins, bcr-abl / DNA Repair / Histone Deacetylase 1 / Histone Deacetylase 2 Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2018 Type: Article Affiliation country: United States