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Initial Treatment of Cancer Patients with Fluconazole-Susceptible Dose-Dependent Candida glabrata Fungemia: Better Outcome with an Echinocandin or Polyene Compared to an Azole?
Le, Audrey; Farmakiotis, Dimitrios; Tarrand, Jeffrey J; Kontoyiannis, Dimitrios P.
Affiliation
  • Le A; Department of Internal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Farmakiotis D; Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA dimitrios.farmakiotis@lifespan.org dkontoyi@mdanderson.org.
  • Tarrand JJ; Department of Laboratory Medicine, the University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
  • Kontoyiannis DP; Department of Infectious Diseases, Infection Control and Employee Health, the University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA dimitrios.farmakiotis@lifespan.org dkontoyi@mdanderson.org.
Antimicrob Agents Chemother ; 61(8)2017 08.
Article in En | MEDLINE | ID: mdl-28584138
ABSTRACT
The 28-day crude mortality rate in 68 cancer patients with fluconazole-susceptible dose-dependent Candida glabrata fungemia started on treatment (within 48 h after blood culture collection) with an echinocandin or liposomal amphotericin-B was better (30%) than those treated with azole monotherapy (52%) (P = 0.07). After adjusting for confounders, azole monotherapy also was associated with worse 28-day survival (hazard ratio, 3.8; P = 0.003).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyenes / Azoles / Fluconazole / Amphotericin B / Candida glabrata / Echinocandins / Candidemia / Antifungal Agents Type of study: Observational_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyenes / Azoles / Fluconazole / Amphotericin B / Candida glabrata / Echinocandins / Candidemia / Antifungal Agents Type of study: Observational_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: United States