Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?

Lange, Sigrun; Gallagher, Mark; Kholia, Sharad; Kosgodage, Uchini S; Hristova, Mariya; Hardy, John; Inal, Jameel M

Lange, Sigrun; Gallagher, Mark; Kholia, Sharad; Kosgodage, Uchini S; Hristova, Mariya; Hardy, John; Inal, Jameel M.

Affiliation

Lange S; Department of Biomedical Sciences, University of Westminster, 115, New Cavendish Street, London W1W 6UW, UK. S.Lange@westminster.ac.uk.
Gallagher M; School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. S.Lange@westminster.ac.uk.
Kholia S; Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK. m.gallagher@londonmet.ac.uk.
Kosgodage US; Molecular Biotechnology Center, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy. sharad.kholia@gmail.com.
Hristova M; Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK. uck0002@my.londonmet.ac.uk.
Hardy J; Institute for Women's Health, University College London, 74 Huntley Street, London WC1N 6HX, UK. m.hristova@ucl.ac.uk.
Inal JM; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK. j.hardy@ucl.ac.uk.

Int J Mol Sci ; 18(6)2017 Jun 05.

Article in En | MEDLINE | ID: mdl-28587234

Subject(s)

Cell-Derived Microparticles/metabolism; Exosomes/metabolism; Neoplasms/metabolism; Neurodegenerative Diseases/metabolism; Protein-Arginine Deiminases/metabolism; Animals; Central Nervous System/drug effects; Central Nervous System/metabolism; Central Nervous System/pathology; Cytoskeleton/metabolism; Enzyme Inhibitors/pharmacology; Epigenesis, Genetic; Extracellular Vesicles/metabolism; Histones/metabolism; Humans; Neoplasms/genetics; Neoplasms/pathology; Neoplasms/therapy; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/therapy; Neuroprotective Agents/pharmacology; Protein Binding; Protein Processing, Post-Translational; Protein-Arginine Deiminases/antagonists & inhibitors

Key words

Chlor-amidine (Cl-Am); cancer; cytoskeleton; deimination; epigenetics; exosomes; extracellular vesicles (EVs); histone H3; induced pluripotent stem cells (iPSCs); microvesicles (MVs); neurodegeneration; peptidylarginine deiminases (PADs)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Cell-Derived Microparticles / Exosomes / Protein-Arginine Deiminases / Neoplasms Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2017 Type: Article Affiliation country: United kingdom

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