Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.

Zhang, Kai; Foster, Helen E; Rondelet, Arnaud; Lacey, Samuel E; Bahi-Buisson, Nadia; Bird, Alexander W; Carter, Andrew P

Zhang, Kai; Foster, Helen E; Rondelet, Arnaud; Lacey, Samuel E; Bahi-Buisson, Nadia; Bird, Alexander W; Carter, Andrew P.

Affiliation

Zhang K; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Foster HE; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Rondelet A; Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Lacey SE; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Bahi-Buisson N; Department of Pediatric Neurology, Université Paris Descartes, Imaging Institute, INSERM U781, Paris, France.
Bird AW; Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Carter AP; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: cartera@mrc-lmb.cam.ac.uk.

Cell ; 169(7): 1303-1314.e18, 2017 Jun 15.

Article in En | MEDLINE | ID: mdl-28602352

Subject(s)

Cytoplasmic Dyneins/chemistry; Multiprotein Complexes/chemistry; Animals; Cryoelectron Microscopy; Cytoplasmic Dyneins/metabolism; Cytoplasmic Dyneins/ultrastructure; Dimerization; Dynactin Complex/chemistry; Dynactin Complex/metabolism; Humans; Mice; Microtubules/chemistry; Microtubules/metabolism; Models, Molecular; Molecular Motor Proteins/chemistry; Molecular Motor Proteins/metabolism; Multiprotein Complexes/metabolism; Multiprotein Complexes/ultrastructure; Sf9 Cells; Spodoptera; Swine

Key words

activation; auto-inhibition; cryo-EM; dynactin; dynein; microtubule; motor; phi-particle

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiprotein Complexes / Cytoplasmic Dyneins Limits: Animals / Humans Language: En Journal: Cell Year: 2017 Type: Article Affiliation country: United kingdom

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