The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.
Nat Rev Mol Cell Biol
; 18(10): 610-621, 2017 Oct.
Article
in En
| MEDLINE
| ID: mdl-28676700
ABSTRACT
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin Assembly and Disassembly
/
DNA Repair
/
Poly (ADP-Ribose) Polymerase-1
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Mol Cell Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2017
Type:
Article
Affiliation country:
Netherlands