Perinatal Outcomes of Non-Primary Maternal Cytomegalovirus Infection: A 15-Year Experience.
Fetal Diagn Ther
; 43(2): 138-142, 2018.
Article
in En
| MEDLINE
| ID: mdl-28697499
ABSTRACT
OBJECTIVE:
To evaluate perinatal outcomes in case of non-primary maternal cytomegalovirus (CMV) infection.METHODS:
We performed a retrospective cohort study of pregnant women with active CMV infection referred to our unit over a 15-year period (January 2000 to December 2014). Non-primary infection was diagnosed on the basis of the results of confirmatory serological and virological tests (avidity test, immunoblotting, real-time PCR-DNA). The vertical transmission rate and the percentage of symptomatic congenital infection were determined in this group of patients.RESULTS:
A total of 205 pregnant women were enrolled. Congenital infection occurred in 7 (3.4%) fetuses/neonates. Symptomatic disease was present at birth in 3 of the 7 congenitally infected neonates (1.5%). Two out of 3 symptomatic newborns presented a pathologic second-trimester ultrasound scan.CONCLUSION:
Maternal immunity offers substantial protection against intrauterine transmission of CMV infection, but not against disease once the fetus is infected.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Ultrasonography, Prenatal
/
Cytomegalovirus Infections
/
Infectious Disease Transmission, Vertical
/
Cytomegalovirus
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Fetal Diagn Ther
Journal subject:
DIAGNOSTICO POR IMAGEM
/
OBSTETRICIA
/
PERINATOLOGIA
Year:
2018
Type:
Article
Affiliation country:
Italy