WP1066, a small molecule inhibitor of the JAK/STAT3 pathway, inhibits ceramide glucosyltransferase activity.

Tsurumaki, Hirotaka; Katano, Hikaru; Sato, Kousuke; Imai, Ryou; Niino, Satomi; Hirabayashi, Yoshio; Ichikawa, Shinichi

Tsurumaki, Hirotaka; Katano, Hikaru; Sato, Kousuke; Imai, Ryou; Niino, Satomi; Hirabayashi, Yoshio; Ichikawa, Shinichi.

Affiliation

Tsurumaki H; Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan.
Katano H; Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan.
Sato K; Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan.
Imai R; Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan.
Niino S; Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan.
Hirabayashi Y; Laboratory for Molecular Membrane Neuroscience, Brain Science Institute (BSI), The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama 351-01, Japan.
Ichikawa S; Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan. Electronic address: shin@nupals.ac.jp.

Biochem Biophys Res Commun ; 491(2): 265-270, 2017 09 16.

Article in En | MEDLINE | ID: mdl-28739255

Subject(s)

Enzyme Inhibitors/pharmacology; Glucosyltransferases/antagonists & inhibitors; Melanocytes/drug effects; Pyridines/pharmacology; Small Molecule Libraries/pharmacology; Tyrphostins/pharmacology; 4-Chloro-7-nitrobenzofurazan/analogs & derivatives; 4-Chloro-7-nitrobenzofurazan/chemistry; 4-Chloro-7-nitrobenzofurazan/metabolism; Animals; Cell Line; Ceramides/chemistry; Ceramides/metabolism; Enzyme Assays; Enzyme Inhibitors/chemistry; Gene Expression; Glucosyltransferases/genetics; Glucosyltransferases/metabolism; Humans; Janus Kinases/antagonists & inhibitors; Janus Kinases/genetics; Janus Kinases/metabolism; Kinetics; Melanocytes/cytology; Melanocytes/enzymology; Pyridines/chemistry; Rats; STAT3 Transcription Factor/antagonists & inhibitors; STAT3 Transcription Factor/genetics; STAT3 Transcription Factor/metabolism; Signal Transduction; Small Molecule Libraries/chemistry; Tyrphostins/chemistry; Uridine Diphosphate Glucose/chemistry; Uridine Diphosphate Glucose/metabolism

Key words

Cell death; Glucosylceramide; Inhibitor; STAT3

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Tyrphostins / Enzyme Inhibitors / Small Molecule Libraries / Glucosyltransferases / Melanocytes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2017 Type: Article Affiliation country: Japan

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