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Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial).
Bella, Eleonora Dalla; Tramacere, Irene; Antonini, Giovanni; Borghero, Giuseppe; Capasso, Margherita; Caponnetto, Claudia; Chiò, Adriano; Corbo, Massimo; Eleopra, Roberto; Filosto, Massimiliano; Giannini, Fabio; Granieri, Enrico; Bella, Vincenzo La; Lunetta, Christian; Mandrioli, Jessica; Mazzini, Letizia; Messina, Sonia; Monsurrò, Maria Rosaria; Mora, Gabriele; Riva, Nilo; Rizzi, Romana; Siciliano, Gabriele; Silani, Vincenzo; Simone, Isabella; Sorarù, Gianni; Volanti, Paolo; Lauria, Giuseppe.
Affiliation
  • Bella ED; 3rd Neurology Unit and ALS Centre, IRCCS 'Carlo Besta' Neurological Institute, Milan, Italy.
  • Tramacere I; Scientific Direction, IRCCS 'Carlo Besta' Neurological Institute, Milan, Italy.
  • Antonini G; Neuromuscular Disease Unit, Sant'Andrea Hospital and University of Rome 'Sapienza', Rome, Italy.
  • Borghero G; Neurologic Unit, Monserrato University Hospital, Cagliari University, Cagliari, Italy.
  • Capasso M; Neurologic Clinic, SS Annunziata Hospital, Chieti, Italy.
  • Caponnetto C; Department of Neurosciences, Rehabilitation Ophthalmology, Genetics, Mother and Child Disease, IRCCS University Hospital San Martino IST, Genova, Italy.
  • Chiò A; Department of Neurosciences, ALS Centre, 'Rita Levi Montalcini', University of Turin and Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.
  • Corbo M; Department of Neurorehabilitation, Casa Cura Policlinico, Milan, Italy.
  • Eleopra R; Neurology Unit, S Maria della Misericordia University Hospital, Udine, Italy.
  • Filosto M; Neurologic Clinic, University of Brescia, Brescia, Italy.
  • Giannini F; Department of Medical and Surgery Sciences and Neurosciences, University of Siena, Siena, Italy.
  • Granieri E; Neurologic Clinic, University of Ferrara, Ferrara, Italy.
  • Bella V; ALS Research Centre, BioNeC, University of Palermo, Palermo, Italy.
  • Lunetta C; NEuroMuscular Omnicenter, Serena Onlus Foundation, Milan, Italy.
  • Mandrioli J; Department of Neurosciences, S Agostino-Estense Hospital, Modena, Italy.
  • Mazzini L; ALS Centre, Neurologic Clinic, Maggiore della Carità University Hospital, Novara;, Italy.
  • Messina S; NEMO SUD Clinical Centre, Messina, Italy.
  • Monsurrò MR; 2nd Neurologic Clinic, 2nd University of Naples, Naples, Italy.
  • Mora G; ALS Center, 'Salvatore Maugeri' Clinical-Scientific Institutes, Milan, Italy.
  • Riva N; Department of Neurology IRCCS 'San Raffaele' Hospital, Milan, Italy.
  • Rizzi R; Neurology Unit, Department of Neuro-Motor Diseases, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
  • Siciliano G; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
  • Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano - Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy.
  • Simone I; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy.
  • Sorarù G; Department of Neurosciences, University of Padua, Padua, Italy.
  • Volanti P; Intensive Neurorehabilitation Unit, IRCCS 'Salvatore Maugeri' Foundation, Mistretta, Italy.
  • Lauria G; 3rd Neurology Unit and ALS Centre, IRCCS 'Carlo Besta' Neurological Institute, Milan, Italy.
BMJ Open ; 7(8): e015434, 2017 08 11.
Article in En | MEDLINE | ID: mdl-28801400
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteostasis Deficiencies / Adrenergic alpha-2 Receptor Agonists / Endoplasmic Reticulum Stress / Guanabenz / Amyotrophic Lateral Sclerosis Type of study: Clinical_trials / Guideline / Prognostic_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: BMJ Open Year: 2017 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteostasis Deficiencies / Adrenergic alpha-2 Receptor Agonists / Endoplasmic Reticulum Stress / Guanabenz / Amyotrophic Lateral Sclerosis Type of study: Clinical_trials / Guideline / Prognostic_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: BMJ Open Year: 2017 Type: Article Affiliation country: Italy